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- 1866
- Foundation of Anglo-Swiss Condensed Milk Co.
- 1867
- Henry Nestlé's Infant cereal developed
- 1905
- Nestlé and Anglo Swiss Condensed Milk Co. (new name after merger)
- 1929
- Merger with Peter, Cailler, Kohler Chocolats Suisses S.A.
- 1934
- Launch of Milo
- 1938
- Launch of Nescafé
- 1947
- Nestlé Alimentana S.A. (new name after merger with Maggi)
- 1948
- Launch of Nestea and Nesquik
- 1969
- Vittel (initially equity interest only)
- 1971
- Merger with Ursina-Franck
- 1973
- Stouffer's (with Lean Cuisine)
- 1974
- L'Oréal (associate)
- 1977
- Nestlé S.A. (new company name)
- Alcon (2002: partial IPO; 2008: partial sale)
- 1981
- Galderma (joint venture with L'Oréal)
- 1985
- Carnation (with Coffee-mate and Friskies)
- 1986
- Creation of Nestlé Nespresso S.A.
- 1988
- Buitoni-Perugina, Rowntree (with KitKat)
- 1990
- Cereal Partners Worldwide (joint venture with General Mills)
- 1991
- Beverage Partners Worldwide (joint venture with Coca-Cola)
- 1992
- Perrier (with Poland Spring)
- 1993
- Creation of Nestlé Sources Internationales (2002: Nestlé Waters)
- 1997
- Creation of Nutrition Strategic Business Division (2006: Nestlé Nutrition)
- 1998
- San Pellegrino and Spillers Petfoods
- Launch of Nestlé Pure Life
- 2000
- PowerBar
- 2001
- Ralston Purina
- 2002
- Schöller and Chef America
- Dairy Partners Americas (joint venture with Fonterra)
- Laboratoires innéov (joint venture with L'Oréal)
- 2003
- Mövenpick and Dreyer's
- 2005
- Wagner, Protéika and Musashi
- 2006
- Creation of FoodServices Strategic Business Division (2009: Nestlé Professional)
- Lactalis Nestlé Produits Frais (associate)
- Jenny Craig, Uncle Tobys and Delta Ice Cream
- 2007
- Novartis Medical Nutrition, Gerber and Henniez
- 2008
- Ruzanna
- 2009
- Vitality Beverage business
- 2010
- Kraft Food's frozen pizza, Waggin'Train, Malher, Technocom and Vitaflo
- Creation of Nestlé Health Science and Nestlé Institute of Health Sciences
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